Method-related interference in thyroid function assays
نویسندگان
چکیده
منابع مشابه
Antibody interference in thyroid assays: a potential for clinical misinformation.
Measurements of thyrotropin and of total and free thyroxine and triiodothyronine are widely used diagnostic methods for thyroid function evaluation. However, some serum samples will demonstrate a nonspecific binding with assay reagents that can interfere with the measurement of these hormones. Several recent case reports have described the presence of such interferences resulting in reported ab...
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Background: One of the most common endocrine problems in major beta-thalassemia is hypothyroidism (HT). The aim of this study was to evaluate thyroid function status in major beta-thalassemia patients older than 10 years old. Methods: This cross sectional study was carried out on thalassemia major patients registered on Thalassemia Center of Amirkola Children Hospital in Babol. A questionnaire ...
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Three women are described from a study of patients with postpartum thyroiditis whose sera gave spuriously increased concentrations of free thyroid hormone because of antibody binding of radiolabeled thyroxin (T4) and triiodothyronine (T3) analogs. All of the women showed increased serum concentrations of thyroid autoantibodies. The antibody binding of radiolabeled analogs and its effect on free...
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Despite the advent modern immunoassays, particularly with regards to TSH measurements, clinicians still encounter seemingly inexplicable results of thyroid function tests, for instance raised concentrations of free hormones (free T4 and/or free T3) in the setting of high, or at least not suppressed TSH concentrations. Though cases of TSH-oma or thyroid hormone resistance do exist, they are in f...
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One agent used by ophthalmologists to aid in funduscopic examinations is sodium fluorescein (“Funduscein,” Cooper Vision). We recently received a patient’s specimen for measurement of thyroxin (T4) and T3-uptake, drawn one day after she had been examined by an ophthalmologist. Owing to the high background fluorescence (62 580 arb.units) and low background polarization (24 mPol), no results were...
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ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2019
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.19-2-s57